46 and 2 is Carl Jung's thoughts concerning (and later expounded upon by Drunvalo Melchizedek) the possibility of reaching a state of evolution at which the body would have two more than the normal 46 total chromosomes and leave a currently disharmonious state. The premise is that humans would deviate from the current state of human DNA which contains 44 autosomes and 2 sex chromosomes. The next step of evolution would likely result in human DNA being reorganized into 46 and 2 chromosomes
Ha! You thought you were going to get through the day without learning something... Sucker!